In the case of PCSK9, use of therapeutic miRs mimic miR-224, miR-132 and miR-499, miR-185, and miR-342, and also inhibition of miR-27a can downregulate PCSK9 expression, and therefore, can also lower elevated LDL-C in FH patients. The gene discussed is PCSK9; the disease is familial hyperaldosteronism.