Furthermore, the common LPL p.S474X (also known as p.S447X) gain-of-function variant has long been associated with reduced TG, increased HDL-C, and reduced CHD risk in small cohorts [54], while the relatively common LPL p.D36N loss-of-function variant has been associated not only with increased TG and increased CHD risk but also with reduced HDL-C [53]. The gene discussed is LPL; the disease is coronary artery disorder.