In particular, extracellular ATP strongly regulates the migrating capacity of cancer cells, which is a critical determinant of cancer invasion or metastasis giving rise to the high casualty [141], and the P2X7 [142–145] and P2Y2 receptors [86, 146–151] have been shown to play a critical role in mediating such ATP-induced regulation of cancer cell migration. Here, P2RX7 is linked to cancer.