The immunologic effects include enhancing the antigen-presenting cell (mainly dendritic cells) activity and cross-presentation of tumor antigens to CD8+ T-cells (e.g., methotrexate), increasing HLA class I antigen expression (e.g., gemcitabine, oxaliplatin, cyclophosphamide), favorable modification of helper T-cell polarization, and inhibition of immuno suppressor cells [mainly FOXP3+ T regulatory (Treg) cells, and myeloid-derived suppressor cells (MDSCs)] (e.g., vincristine, docetaxel, paclitaxel) (16, 32). This evidence concerns the gene CD8A and neoplasm.