Five factors (Male gender (p=0.005), CD4 count <350 cells/mm3, (p=0.035), unknown CD4 count (p=0.048), tuberculosis (p=0.033) and renal failure (p=0.013)) were found to be independently associated with a higher risk of IHM in the logistic regression analysis (Table 3). The gene discussed is CD4; the disease is kidney failure.