Other strongly linked hematological malignancies, such as chronic neutrophilic leukemia (CNL), CMML, unclassified MDS, myeloproliferative neoplasms (MPNs), and secondary acute myelocytic leukemia (AML) evolving from MDS [25–29], are also related to SETBP1. Despite the fact that mutations in both ASXL1 and SETBP1 are generally associated with an adverse prognosis [20, 21, 26, 30], our patient’s symptoms seemed not to be related to his mutations in these genes. Here, ASXL1 is linked to chronic myelomonocytic leukemia.