Then, it was shown that the monoclonal MOG-specific Ab 8–18C5 induces demyelination in Lewis (LEW) rats with experimental autoimmune encephalomyelitis (EAE) (4, 22), that guinea pigs immunized with M2 show demyelinated lesions in their CNS, and that the M2 protein is identical to MOG (16). Here, MOG is linked to experimental autoimmune encephalomyelitis.