EAE phenotype in marmosets correlates with the availability of conformational MOG Abs resulting in typical multiple sclerosis-like disease pattern. In addition Abs to MOG peptides lead to focal disease pattern in brain stem and spinal cord. MBP T cell-mediated EAE animals showed no demyelination when injected with MOG peptides. By contrast, conformational MOG Abs were more pathologic as controls. Here, MOG is linked to multiple sclerosis.