IFNB1 and demyelinating disease of central nervous system: Excluding the patients who developed AITD following commencement of IFN-β treatment, the onset of AITD preceded that of CNS demyelinating disease in 17 patients, developed at the same time in 3 cases (including two of the patients with NMOSD), followed the onset of CNS demyelinating disease in 17 cases, and was unknown for 3 cases.