Compared with these anti-cancer roles, the ACE2/Ang-(1–7)/Mas axis has been shown to promote the migration and invasion of renal cell carcinoma (Zheng et al., 2015) and mediate the AngII-induced epithelial-mesenchymal transition (EMT) in tubule cells (Burns et al., 2010). Here, MAS1 is linked to hereditary clear cell renal cell carcinoma.