The up-regulation of the ACE2/Ang-(1–7)/MasR axis promotes the expression of E-cadherin by suppressing the PAK1/NF-κB/Snail1 pathway, and the activatedACE2/Ang-(1–7)/MasR axis inhibits breast cancer metastasis and store-operated calcium entry (SOCE). This evidence concerns the gene ACE2 and breast cancer.