Another research group revealed that reduced ACE2 expression via RNA interference promotes the proliferation of cultured pancreatic cancer cells, suggesting that the inhibition of ACE2 may have clinical potential as a novel molecular target for the treatment of pancreatic ductal adenocarcinoma and the reduction of cell proliferation (Zhou et al., 2009, 2011). This evidence concerns the gene ACE2 and pancreatic ductal adenocarcinoma.