In further studies, Feng et al. (2011) confirmed that ACE2 overexpression inhibits cell growth and VEGFa production while simultaneously suppressing ACE and Ang II expression in human lung cancer xenografts, and these findings suggest that ACE2 overexpression may suppress the invasion and angiogenesis in NSCLC. The gene discussed is ACE2; the disease is non-small cell lung carcinoma.