Ang-(1–7) has been found to inhibit lung cancer cell growth (Gallagher and Tallant, 2004), but it promotes the migration and invasion of human renal cell carcinoma cells via the Mas-mediated AKT signaling pathway (Zheng et al., 2015), whereas the MasR has been demonstrated to act as an anti-tumor agent in breast cancer (Luo et al., 2015). Here, AKT1 is linked to hereditary clear cell renal cell carcinoma.