However, protocatechuic acid (50 and 100 mg/kg) could significantly reversed IL 1β (p < 0.01), IL 6 (p < 0.01), IL 12 (p < 0.05–0.01), and TNF α (p < 0.01) levels in the sera of T2D rats to near normal status. This evidence concerns the gene TNF and type 2 diabetes mellitus.