Dual OX1/2R and selective OX2R antagonists have been developed as therapeutics for insomnia, and clinical efficacy has been demonstrated for the dual OX1/2R antagonist SB-649868 (Bettica et al., 2012) and the selective OX2R antagonist JNJ-42847922 (Bonaventure et al., 2015a). The gene discussed is HCRTR2; the disease is insomnia.