These beneficial effects of scopolin on hepatic steatosis appear to be associated with increased deacetylation of the SREBP1c protein with subsequent downregulation of lipogenic genes (LXRα, ACC, LPL, and FAS), along with increased deacetylation of the PGC-1α protein with upregulation of genes involved in fatty acid oxidation (PPARα, and CPT1). This evidence concerns the gene PPARA and Hepatic steatosis.