In contrast, c-Rel as a homo-dimer or in association with p50 and p65, repress transcriptional activation by NFκB19 and c-Rel has been previously shown to be a repressor of certain gene promoters in human cells, such as Ephrin type-B receptor 2 (EPHB2) in colorectal cancer cells36. The gene discussed is REL; the disease is colorectal cancer.