As a result, Shenks reduced the oxidative production of protein 3-NT (Figs 5C and 6C) and lipid MDA (Figs 5D and 6D), as well as rescued the content of GSH (Figs 5E and 6E) in the BLM stimulated mice and TGF-β stimulated cell, and the anti-fibrotic ability was comparable with that of NAC (Fig. 5). The gene discussed is TGFB1; the disease is Bloom syndrome.