In a combined analysis in 60 APC mutation carriers and their 58 untested relatives with FAP associated cancer or benign manifestation, the phenotypic features observed were 79 CRC, 5 upper GI cancers, 3 thyroid cancer, 2 brain tumors, 13 desmoid tumors/fibromatosis. The gene discussed is APC; the disease is Familial adenomatous polyposis.