Importantly, it is known that during LPS- induced endotoxemia, animal death is accompanied by major dysfunctions of vital organs that can be monitored by measuring levels of circulating ALT, AST, BUN and glucose32 of utmost interest, the extreme sensitivity of Ptpn6H-KO mice to LPS-mediated endotoxemia and death was also reflected by rapid and intense collapse of organs’ function as exacerbated levels of these pathological markers were detected. The gene discussed is GPT; the disease is serum lipopolysaccharide activity.