Accordingly, 1,102 primary breast tumors including all major molecular subtypes, were classified into those with a non-T cell-inflamed and those with T cell-inflamed phenotype based of the expression level of T cell specific markers (FYB, LCP2, CD3E, CD8A, CD28), different chemokines associated with CD8+ T cell recruitment (CCL5, CCl2, CCl3, CCL4, CXCL9, CXCL10) and IFN-induced genes (IFI16, IFIH1, GBP1, OAS2, MX1). Here, CD28 is linked to breast neoplasm.