To further investigate if IL-1R8 expression in tumor cells could induce M2-macrophage polarization, THP-1 macrophage-like cells [34] were cultured in the presence of conditioned medium from IL-1β-stimulated HB4aHER2+ and HB4aHER2+/IL1R8KD cells. Here, IL1RAPL1 is linked to neoplasm.