SIGIRR and breast neoplasm: Approximately, 64% of all breast tumors expressed lower expression levels of the 16 T-cell inflamed signature genes (709/1,102) and, noteworthy, the majority of IL-1R8 high tumors were clustered in the group of tumors expressing lower levels of T-cell inflamed signature genes (394/551, 72%, P = 6.758e-07, Figure 5A).