Finally, lower levels of several pro-inflammatory cytokines (IL1B, IL10, IL12, IL6, IL8, TNF), NK cell metagenes (NCR1, XCL1), cytolytic enzymes (GZMA, GZMB, PRF) and type I IFN-induced genes were also observed in IL-1R8 high breast tumors (Table 1 and Supplementary Table 2). Here, SIGIRR is linked to breast neoplasm.