CD8A and neoplasm: ILRs and TLRs activation ignites a signal transduction cascade with pro-inflammatory outcomes, including the activation of NF-κB and the secretion of pro-inflammatory cytokines such as Type I IFNs and TNFα, which are in turn necessary for natural killer (NK) and dendritic cell (DC) activation, together with CD8+ T cell priming against tumor antigens and trafficking into the TME [8–10].