SIGIRR and B-cell chronic lymphocytic leukemia: In addition, IL-1R8-deficiency in mice results in more severe gut inflammation during dextran sulfate sodium colitis [22, 23], increased susceptibility to colitis-associated colorectal cancer [23–25], and more severe and earlier onset of monoclonal B cell expansions in a murine model of chronic lymphocytic leukemia (CLL) [26].