Recently an interesting dual role for c-MYC in CML has been reported: Reavie L. et al. showed that both depletion and overexpression of c-MYC can severely impact CML progression, suggesting that a specific level of c-Myc protein is essential for CML induction and progression [31]. Here, MYC is linked to chronic myelogenous leukemia, BCR-ABL1 positive.