CABLES1 gene inactivation by allelic loss, aberrant splicing or promoter hypermethylation has been observed in different types of human cancers but, to our knowledge, it has not been explored in pituitary adenomas before (Tan et al. 2003, Zhang et al. 2005, Sakamoto et al. 2008). This evidence concerns the gene CABLES1 and pituitary gland adenoma.