The absence of this somatic defect somehow mirrors the absence of GNAS1 mutations in patients with somatotropinomas due to AIP mutations, suggesting that the genetic defects causing tumors due to germline predisposition are different than those found in non-inherited pituitary adenomas (Hernández-Ramírez et al. 2015). This evidence concerns the gene AIP and growth hormone-producing pituitary gland neoplasm.