INS and Insulin resistance: 2013). In fact, after 12 weeks, COX‐2 mediated events may be related to the induction of insulin resistance in a model of high‐fat diet‐induced obesity (Tian et al. 2011). Previous authors observed an increase in COX‐2 and subsequent insulin resistance in adipose tissue and glycolytic muscles, but not the rat soleus muscle (Tian et al. 2011).