TNFRSF8 and mycosis fungoides: Diagnosis of transformed MF (T-MF) is based on the presence of large cells (CD30 +/-) exceeding 25% of the infiltrate throughout the lesion or forming microscopic nodules of large cells[3]. Molecular studies have demonstrated that the large-cell infiltrate in T-MF/Sezary syndrome (SS) represents evolution from the original clone [4].