Segregation by WHO grade was prognostic within the astrocytic glioma/glioblastoma, IDH-mutant cluster, yielding a median overall survival of 34.1 months (WHO Grade IV), 68.4 months (WHO Grade III) and 95.8 months (WHO Grade II), respectively (p = 0.007, Cox proportional hazards regression, Fig. 7b). Here, IDH2 is linked to glioblastoma.