IDH2 and glioblastoma: For the most common type of diffuse glioma, i.e. glioblastoma, IDH-wildtype, WHO Grade IV, there is a difference in overall survival across the W1–W3 molecular subtypes (p = 0.002, Cox proportional hazards regression, Fig. 7a), with median overall survival of 6.6 months (W1), 12.7 months (W2) and 15.2 months (W3), respectively.