In previous studies, non-cytophilic classes (IgG2) also predominated among the anti-malarial antibodies developed by unprotected subjects, whereas cytophilic subclasses (IgG1 and mainly IgG3) were the most abundant isotypes produced by malaria patients, who are protected from malarial parasites [21, 22]. This evidence concerns the gene IGHG3 and malaria.