Gene and protein expression studies performed in epithelial breast cancer cell lines, primary breast tumors and in chemically-induced murine mammary breast tumors demonstrated that increased IKKε levels can also result from aberrant expression without gene amplification suggesting that analysis at genomic levels is not appropriate to fully characterize IKKε status in breast cancer [13, 14, 20]. The gene discussed is IKBKE; the disease is breast neoplasm.