TDP2 and hepatocellular carcinoma: TDP2, though not TDP1, was able to release P protein from HBV and DHBV RC-DNA in vitro, and RNA interference-mediated depletion of TDP2 from human hepatoma cells significantly slowed down DHBV RC- to cccDNA conversion [49]; however, cccDNA formation was not ablated even upon TDP2 knock-out [76].