IL18 and neurodegenerative disease: IL-18 can enhance Aβ production [42] and the kinases Cdk5 and glycogen synthase kinase-3β (GSK-3β), which are involved in the hyperphosphorylation of tau [14], caspase-1 regulation as well as many other neurodegenerative diseases linked proteins [40], and cellular vacuolization [42].