An in vitro study showed that black tea infusion (150 mL with 2.5 g) suppressed expression of the inflammatory cytokines TNF-α, IL-1β and IL-6, while it increased IFN-Υ, suggesting black tea had a selective pro-inflammatory cytokine that can also reduce IL-1β and IFN-Υ in insulinoma cell and inducible NO synthase (iNOS) gene expression suppressive effect [68]. The gene discussed is IL1B; the disease is pancreatic insulinoma.