Type 1 DM (T1DM) is a metabolic disease characterized by an insulin secretory defect due to the autoimmune destruction of the beta cells in the pancreas [4] and type 2 DM (T2DM) is a long term metabolic disorder characterized by high blood sugar (hyperglycemia), insulin resistance, and relative lack of insulin [5]. This evidence concerns the gene INS and type 1 diabetes mellitus.