AKT1 and cardiac hypertrophy: Sirtuins induce the deacetylation of forkhead box O (FoxO), NF-κB, protein kinase B (Akt), p53, superoxide dismutase (SOD), and members of ETC complex I and influence fatty acid oxidation, cardiac hypertrophy, ischemia/reperfusion (I/R) injury, apoptosis, oxidative stress and autophagy in cardiomyocytes [8].