More recently, it has been showed that CD133+ cells purified from endometrioid adenocarcinomas are resistant to cisplatin-induced and paclitaxel-induced cytotoxicity and express a peculiar gene signature consisting of high levels of matrix metalloproteases, interleukin-8, CD44, and CXCR4. The gene discussed is CXCR4; the disease is endometrioid adenocarcinoma.