ERBB2 and neoplasm: Similarly, T-DM1 was highly active in the reduction of tumor formation in vivo in control xenografts that overexpressed HER2 (p = 0.0001 and p < 0.0001 compared to T and vehicle, respectively), with a highly longer survival time in comparison with T and vehicle mice (p = 0.008 and p = 0.0001, respectively) [2].