Interestingly, p53 expression remained impassive in both stipulations.6, 7 Further, the potential significance of p21 in cancer biology has been underscored in human melanoma cells and chronic myeloid leukemia wherein, the comparison between wild-type cells and p21 deleted cells underscored the dual nature of p21 owing to its ability to hamper cell proliferation and drug-induced apoptosis.10, 11 Compelling recent evidences have suggested the involvement of AKT in ER stress-induced apoptosis. This evidence concerns the gene CDKN1A and melanoma.