However, keeping in view that 3-AWA is a strong Par-4 inducer as well as a negative regulator of antiapoptotic p21, we investigated the physiologically relevant effects of 3-AWA on orthotopic tumor growth and we found that 3-AWA inhibits colorectal tumor growth and formation of colorectal polyps at a tolerable dose of 10 mg/kg, which was similar to the first-line drug for colorectal cancer-5-fluorouracil. This evidence concerns the gene CDKN1A and polyp of large intestine.