CDKN1A and neoplasm: 3-AWA is a strong inducer of a proapoptotic tumor-suppressor protein Par-4.16 Therefore, inhibition of 3-AWA-mediated p21 downmodulation by neutralizing ER stress (through Salubrinal/Figure 1c) prompted us to dissect any relation between ER stress and Par-4 in regulating 3-AWA-mediated p21 downregulation.