CCN5 and breast cancer: CCN5 (previously known as WISP-2), a matricellular protein, is expressed in normaland non-invasive breast epithelial cells and is becoming an increasingly importantfocus in BC research.24, 25, 26 Multiple studies haveshown that CCN5-overexpressed BC cells are less aggressive in nature compared toCCN5-under-expressed or -negative BC cells.