CDK5 kinase drives tumor progression and metastasis across various malignancies via different mechanisms in a tissue-specific manner.60, 61, 62, 63 Of interest, recent reports suggest involvement of aberrant CDK5 signaling in migration of endothelial cells, lymphangiogenesis and formation of blood vessels.64, 65 These findings, taken together, support the hypothesis that TRPV4 overexpression may create a pro-metastatic microenvironment that supports cancer progression by secreting tumor-derived proteins and/or exosomes. Here, CDK5 is linked to cancer.