TRPV4 and breast carcinoma: Using the phosphoproteomics approach, our lab previously identified TRPV4 to play a role in breast cancer metastasis.15 Furthermore, meta-analysis of public databases through multifunctional online tools (http://co.bmc.lu.se/gobo,http://kmplot.com/analysis), TRPV4 expression in breast cancer patients was shown to correlate with a more aggressive phenotype, a poorer overall and distant metastasis-free survival (DMFS) in a multivariate analyses.15