While Zaninetti et al.43 showed that TRPV4 activation reduced migration of neuroendocrine cells, Martin et al. and Fiorio et al. found TRPV4 to be capable of mediating migration of pulmonary artery smooth muscle and AA-induced migration of endothelial cells, respectively.14, 44 In this study, we showed that TRPV4-mediated AKT pathway is crucial for transendothelial migration of breast cancer cells. Here, TRPV4 is linked to breast cancer.