The specific roles of the 5 genes, Fn1, Clu, Tubb2c, Tln1 and Spp1 identified to be involved in the above-mentioned process networks, with respect to TRPV4 functions remained to be investigated but genes such as Talin (Tln1, upregulated by TRPV4) is well known to promote metastasis.27 Other genes upregulated by TRPV4, for example, Transgelin, Trim28 and Hdgf are also involved in cancer progression28, 29, 30, 31, 32, 33, 34, 35 and could also potentially mediate metastasis following exosomes uptake by neighboring cells. The gene discussed is SPP1; the disease is cancer.