Many studies suggested its role in tumorigenesis, migration and metastasis.53, 54, 55 Moreover, high levels of Talin in the blood serum has been detected in the patients with colon and liver.56, 57 In a recent study by Sakamoto et al.55, Talin was found to engage in focal adhesion interactions with the AKT signaling as the intracellular survival mechanisms to confer anoikis resistance and promote prostate cancer cell invasion. This evidence concerns the gene AKT1 and Familial prostate cancer.