TWEAK alone had some effect on chemokine production in vitro in keratinocytes, but this was broadened and enhanced by synergistic signals from IL-13 and IL-17, two of the primary factors critical for the pathogenesis of AD and psoriasis, respectively, suggesting the likelihood of co-operation in vivo between these cytokines in controlling chemokine expression. The gene discussed is IL13; the disease is Alzheimer disease.