Interestingly, our findings were also not dissimilar to a median CD4 change of 374 cells/mm3 at 48 weeks from a baseline CD4 count of 170 cells/mm3 among 31 children and adolescents aged 9–19 years with perinatal HIV infection starting ART for the first time in a community-based ART programme in Cape Town, South Africa [30]. The gene discussed is CD4; the disease is HIV infectious disease.