FKBP1A and glomerulonephritis: Rapamycin binds to FKBP12 and can inhibit both mTORC1 and, to a lesser extent, mTORC2 signaling(Zeng et al., 2007, Sarbassov et al., 2006).Rapamycin may induce glomerulonephritis and intratubular cast formation in protein overload nephropathy (Coombes et al., 2005, Marti and Frey, 2005).