A range of strategies have been used to overcome the poor replication of ZIKV in WT mice, including (i) injection with anti-Ifnar1 monoclonal antibody (28, 29), (ii) infection via the intraperitoneal route later in pregnancy (E13.5) (30) or infection via the intravaginal route (18) (although fetal brain infection was only detectable by immunofluorescent-antibody staining), (iii) the use of SJL mice and very high doses of virus (22), (vi) direct intrauterine inoculation (31), and (v) infection of neonates (32). The gene discussed is IFNAR1; the disease is infection.