SOCS3 and Autoimmunity: Carow and Rottenberg reported that gene SOCS3, which was also identified as a DCG (fold change = 1.54; p = 0.15), is a major regulator of infection and inflammation and controls immune homeostasis in physiological and pathological conditions such as infection and autoimmunity [43]. SOCS3 is a hub gene in the module lightgreen associated with the Jak-STAT signaling pathway, an important pathway for Salmonella infection [44].