Thus, an IL-6-driven inflammatory feedback loop is a core epigenetic regulator of the dynamic equilibrium that converts non-stem cancer cells into CSC-like cells, and generates tumor heterogeneity in genetically distinct cancer cells (Iliopoulos et al., 2011; Korkaya et al., 2011, 2012; Krishnamurthy et al., 2014). Here, IL6 is linked to neoplasm.