Moreover, whereas para-inflammation-associated SIR is widely prevalent in cancers harboring mutations in p53 (Aran et al., 2016), the capacity for non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin to exert protective effects against several cancers (e.g., colorectal, pancreatic, lung, and breast; Rothwell et al., 2011; Fraser et al., 2014; Streicher et al., 2014) might be related to their ability to suppress key drivers of SIR in poor prognosis, para-inflammated tumors (Aran et al., 2016). Here, TP53 is linked to cancer.