In an independent study of patients undergoing HCT for hematologic malignancies, high levels of soluble HLA-G proteins within the first month after HCT could be recovered in patients who did not develop acute GVHD; the level of soluble HLA-G proteins correlated with the frequency of T regulatory cells with the CD4+ CD25+ CD152+ phenotype in transplant recipients88. The gene discussed is HLA-G; the disease is acute graft versus host disease.