Downregulation of the glucocorticoid receptor or mutations in its signaling pathway could be a plausible explanation of glucocorticoid resistance; however, in ACTH-producing corticotroph adenomas, the expression of the receptor has been found to be increased, and although NR3C1 mutations have been found in cases of CD, these are not frequent17,18. Here, POMC is linked to ACTH-producing pituitary gland adenoma.