NR3C1 and ACTH-producing pituitary gland adenoma: Downregulation of the glucocorticoid receptor or mutations in its signaling pathway could be a plausible explanation of glucocorticoid resistance; however, in ACTH-producing corticotroph adenomas, the expression of the receptor has been found to be increased, and although NR3C1 mutations have been found in cases of CD, these are not frequent17,18.