After adjusting for potential confounders in multivariate cox proportional hazard model, the fasting insulin >20 μIU/ml [adjusted hazard ratio (HR): 3.03, 95% CI 1.41–6.54, p = 0.005] and severity of CAD [adjusted hazard ratio (HR): 2.32, 95% CI 1.07–5.02, p = 0.032] were significantly associated with MACE at 1 year in type 2 diabetes mellitus (Table 4). This evidence concerns the gene INS and coronary artery disorder.