Several studies have reported that the single nucleotide polymorphism (SNP) rs2853669 allele G, located at nucleotide −245 from the TERT ATG start site, down regulates the expression of TERT gene caused by hot spot promoter mutations in several types of cancer including bladder, gliomas, and renal cell cancer [62, 63]. This evidence concerns the gene TERT and renal cell adenocarcinoma.