A mutation can be found in 85% of patients, and the total number of unique DNA variants of over 850 and 2400 for TSC1 and TSC2, respectively, has been shown to cause TSC up to date (Tuberous Sclerosis Database, http://chromium.liacs.nl/LOVD2/TSC/home.php). This evidence concerns the gene TSC2 and tuberous sclerosis.