In addition, a few studies also explored the association between the recurrence risk and polymorphisms, including T393C SNP of Galphas gene (GNAS1), CD40 (rs745307, rs11569309, and rs3765457), and E33SNP of thyroglobulin (Tg) (Tg E33SNP) in GD patients after ATD withdrawal [41, 42, 69]. Here, TG is linked to Jeune syndrome.