Interestingly, two of the validated genes differentially regulated in longissimus dorsi of space-flown mice and linked to insulin resistance, Lcn2 and Sesn1, and another gene coding for Mafb were previously identified as overexpressed genes in both soleus and EDL of mice flown for 30 days onboard the BION-M1 biosatellite (Gambara et al., 2017), suggesting that the regulation of only few genes following microgravity exposure may not be strictly muscle specific. This evidence concerns the gene LCN2 and Insulin resistance.