FMR1 and fragile X-associated tremor/ataxia syndrome: While these data support 5hmC-mediated epigenetic modulation as a player in FXTAS pathogenesis, further studies, such as characterizing the level of 5hmC at the FMR1 locus, are warranted to reveal more about the role of the 5hmC mark in the pathogenic mechanism of FXTAS (Al-Mahdawi et al., 2014).