In the with hypoglycemia groups, 8 proteins, including histone H2B, apolipoprotein C, alpha-2-macroglobulin, inter-alpha-trypsin inhibitor heavy chain H1, inter-alpha-trypsin inhibitor heavy chain H4, complement component C9, biotinidase and complement component C8 gamma chain, exhibited the same abundance changes among the two groups. The gene discussed is ITIH4; the disease is Hypoglycemia.