Numerous studies of allo-transplanted and non-transplanted patients have highlighted the importance of cellular immunity, including aspects of natural killer (NK) cell function, for the outcome of AML.4, 5, 6 In order to identify aberrant cells, NK cells rely on the surface expression of a set of activating receptors such as natural cytotoxicity receptors (NCRs), including NKp46 and NKp30. This evidence concerns the gene NCR1 and acute myeloid leukemia.