KMO and cancer: The regulation of kynurenine enzymes has also been measured: fluoxetine had no effect on KMO mRNA levels when used to prevent the development of depressive-like behavior in a mouse model of cancer related fatigue (Norden et al., 2015), while agomelatine, a melatonergic antidepressant, reversed the LPS-dependent increase in KMO expression in the hippocampus of rats (Molteni et al., 2013).