Thus, the main aspect of this study, which differentiates it from the previous work, is assessment of the activity of CAPE on the colon at macroscopic and microscopic levels, its effect on MPO and pro-inflammatory cytokine levels and altered mucosal permeability in a mouse model of colitis, which is physiologically relevant to human disease (Tambuwala et al. 2015). Here, MPO is linked to colitis.